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Extensively characterized in asian women

Beijing strains of Mycobacterium tuberculosis lineage 2 have been associated with drug-resistance and transmission of tuberculosis worldwide. Most of the Beijing strains identified in the Colombian Pacific coast have exhibited a multidrug resistant MDR phenotype. We sought to evaluate the clonality and sublineage of Beijing strains circulating in Southwestern Colombia. Thirty-seven Beijing strains were identified through spoligotyping out of clinical isolates collected in 9 years from — Drug-resistance associated mutations to first- and second-line anti-TB drugs were also evaluated. Additionally, two Beijing strains were Illumina-whole genome sequenced one MDR and one drug-susceptible.
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Molecular genetics of CYP2D6: Clinical relevance with focus on psychotropic drugs

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Molecular genetics of CYP2D6: Clinical relevance with focus on psychotropic drugs

Among the rest extensive metabolizers , enzyme activity is highly variable, from extremely high in ultrarapid metabolizers, to markedly reduced in intermediate metabolizers. The CYP2D6 gene is highly polymorphic, with more than 70 allelic variants described so far. Of these, more than 15 encode an inactive or no enzyme at all. Many drugs, especially lipophilic compounds such as psychotropics need to be metabolized prior to excretion in urine. Oxidative phase I catalysed metabolism by cytochrome P CYP enzymes plays a major role in this respect. In the s it was shown that the to fold variability in plasma concentrations of the tricyclic antidepressant nortriptyline in patients treated with the same dose is due to a pronounced variation in the rate of metabolism of the drug [ 1 , 2 ]. This short review deals with the molecular genetics of CYP2D6 and its clinical relevance.
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Adoption of Chinese literary culture

Chinese writing, culture and institutions were imported as a whole by Vietnam, Korea, Japan and other neighbouring states over an extended period. Chinese Buddhism spread over East Asia between the 2nd and 5th centuries AD, followed by Confucianism as these countries developed strong central governments modelled on Chinese institutions. In Vietnam and Korea, and for a shorter time in Japan and the Ryukyus , scholar-officials were selected using examinations on the Confucian classics modelled on the Chinese civil service examinations.
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