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Augmentin tissue penetration

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National Center for Biotechnology Information , U. Bull N Y Acad Med. Copyright and License information Disclaimer. Copyright notice.
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Antibiotic tissue penetration.

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Antibiotic tissue penetration.

To be effective, antibiotics must be active against the offending pathogen s and must reach sufficient concentrations at the site of infection where microorganisms have induced severe inflammation. Such inflammation may, depending on the infected tissue, increase or decrease antibiotic penetration. Once it has reached the infected site an antibiotic may be inactivated locally. In this work, we have reviewed: 1. Factors modulating the penetration of antibiotics in tissues of normal and infected humans and animals; 2. The relationship between concentrations and efficacy of antimicrobials in experimental and human infections; 3. The mechanisms by which high tissue levels of antibiotics may be toxic; 4.
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Tissue penetration of antibiotics

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